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BAG5 Antibody (N-Terminus)
Goat Polyclonal Antibody
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Application 
| IHC-P, E |
|---|---|
| Primary Accession | Q9UL15 |
| Reactivity | Human, Mouse, Rat, Hamster, Monkey, Horse, Dog |
| Host | Goat |
| Clonality | Polyclonal |
| Calculated MW | 51kDa |
| Dilution | ELISA (1:64000), IHC-P (3.75 µg/ml), |
| Gene ID | 9529 |
|---|---|
| Other Names | BAG family molecular chaperone regulator 5, BAG-5, Bcl-2-associated athanogene 5, BAG5, KIAA0873 |
| Target/Specificity | Human BAG5. Variants (NP_004864.1; NP_001015048.1) encode the same isoform. |
| Reconstitution & Storage | Store at -20°C. Minimize freezing and thawing. |
| Precautions | BAG5 Antibody (N-Terminus) is for research use only and not for use in diagnostic or therapeutic procedures. |
| Name | BAG5 |
|---|---|
| Synonyms | KIAA0873 |
| Function | Co-chaperone for HSP/HSP70 proteins. It functions as a nucleotide-exchange factor promoting the release of ADP from HSP70, thereby activating HSP70-mediated protein refolding (PubMed:20223214). Has an essential role in maintaining proteostasis at junctional membrane complexes (JMC), where it may function as a scaffold between the HSPA8 chaperone and JMC proteins enabling correct, HSPA8-dependent JMC protein folding (By similarity). Inhibits both auto-ubiquitination of PRKN and ubiquitination of target proteins by PRKN (By similarity). |
| Cellular Location | Note=In cardiomyocytes, localized at specialized membrane contact sites between T-tubules and the sarcoplasmic reticulum, known as junctional membrane complexes {ECO:0000250|UniProtKB:Q8CI32} |
| Tissue Location | Expressed in the heart. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Inhibits both auto-ubiquitination of PARK2 and ubiquitination of target proteins by PARK2 (By similarity). May function as a nucleotide exchange factor for HSP/HSP70, promoting ADP release, and activating Hsp70-mediated refolding.
References
Takayama S.,et al.J. Biol. Chem. 274:781-786(1999).
Nagase T.,et al.DNA Res. 5:355-364(1998).
Heilig R.,et al.Nature 421:601-607(2003).
Burkard T.R.,et al.BMC Syst. Biol. 5:17-17(2011).
Hasson S.A.,et al.Nature 504:291-295(2013).
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